A 83-01 _ 53002ES Recombinant Protein Bioorg Chem

Bioorg Chem

Dose responsecurve for Anti-MSLN Antibody

3390/ma14164674(IF:3

Ser46-Ile113

5 pg/μL unmodified dsRNA standard at three volume ratios (1:1

A 83-01 _ 53002ES Recombinant Protein Bioorg ChemA 83 01 is a potent inhibitor of TGF type I receptor ALK5 (IC50: 12 nM) ALK4 ((IC50: 45 nM) ALK7 (IC50: 7. 5 nM) kinase, A 83 01 has a strong inhibitory effect on ALK5 and can inhibit phosphorylation of Smad2 3 and TGF induced growth. A 83 01 has little or no effect on bone morphogenetic protein type I receptors, p38 mitogen activated protein kinases, or extracellular regulatory kinases. At the same time, A 83 01 inhibits TGF induced epithelial