If paired with a more proactive gameplan (Geist comes to mind), or in a shell that can add new tech (4C Control from SCG Baltimore, rocking Souls in the main), this removal suite is very hard for Infect to deal with
Then, if CARDNAME has no doom counters on it, sacrifice it and put a 5/5 black indestructible Demon token with flying onto the battlefield under an opponent's control
Selfless Savior, Skrelv, Defector Mite, and Mother of Runes are examples of mana-free protection that we can cast before casting our commander (protection from color can also double as evasion!), and we also have cards like Brass Squire which can equip protection for free
It lets you keep good one landers
Temporal Cascade or Reminisce, for example, are important in order not to perish due to a missing library