That said, Flash of Lights awesome flavor and the rarity of targeted removal spells in its color makes it a solid option for Final Fantasy-themed casual play
These kinds of cards will almost always be your best bet here
The other option is to take advantage of the direct damage, which is good in its own right to either finish off a damaged character or get them within range to be banished but also works with the likes of cards that benefit from being damaged - such as Scroop, Backstabber - that benefit from healing damage, like Rapunzel, Gifted Artist, or from damage being dealt: like Beast, Relentless.
Otharri, Suns Glory One of the most lethal Boros creatures you can slip into your Cube, Otharri, Suns' Glory often reminds me of Minsc & Boo, Timeless Heroes
Ripples of Potential This is very similar in concept to Mutational Advantage, but its cheaper and in one color, and phasing is better protection in most cases