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NRX-252262 acts as molecular glue in cells to promote the ubiquitylation and subsequent degradation of mutantbeta-catenin by the 26S proteasome
S)-AHPC-CO-PEG3-C2-acid Synonyms CAS Number 2140807-42-5 Related CAS Molecular Formula C32H46N4O9S Molecular Weight 662
Bottanelli
S)-AHPC-acetamido-O-PEG1-C1-acid Synonyms CAS Number 2172820-08-3 Related CAS Molecular Formula C28H38N4O8S Molecular Weight 590
034 Purity (HPLC) >= 95% Solubility DMSO
Propargyl-Gly(m-PEG4)-Val-Cit-PAB(m-PEG4) Size:100mg NRX-252262 acts as molecular glueSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Propargyl Gly(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The propargyl functional group is widely employed in click chemistry to undergo selective cycloaddition with azides. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. Derived
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