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no side reactions occur – the label and detection tags react selectively and specifically with one another
Small molecule induced polymerization of BCL6 facilitates SIAH1 mediated degradation
as the acetylation masks the hydroxyl groups critical for fluorescein’s fluorescence
789 Purity (HPLC) >= 95% Solubility DMSO
74 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCBr)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
Mal-Propionyl-PEG2-Val-Ala-PAB(m-PEG8)-MMAE mal-acetyl-dap-m-PEG4 no side reactions occur –SOLU KNEX cleavable linker features a Val Ala dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly
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