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Mal-Propionyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan only Product Name Fmoc-Val-Ala-PAB(m-PEG8) Synonyms CAS

SKU: 82012380188

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Description

Product Name Fmoc-Val-Ala-PAB(m-PEG8) Synonyms CAS Number Related CAS Molecular Formula C48H68N4O14 Molecular Weight 925

79 SMILES: CC1(C)\C(=C/C=C/C2=[N+](CCCCCC(=O)OCC#C)C3=CC=CC=C3C2(C)C)N(CCCS([O-])(=O)=O)C2=CC=CC=C12 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

CA-PEG4-Azide can be used to attach azide moiety to protein

Mukhopadhyay

Berishvili

Mal-Propionyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan only Product Name Fmoc-Val-Ala-PAB(m-PEG8) Synonyms CASSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Propionyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is

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