DOTA-tris(t-Bu)ester-PEG6-propargyl fam 4-(1-piperazinyl)-

4-(1-piperazinyl)-

394 SMILES OCCCCCCC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

445 SMILES OCCCCCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

324 SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)C2=CC(NCCC#C)=CC=C12 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

The methyl group is inert in this context and cannot undergo the nucleophilic substitution reaction that the chloroalkane relies on to bind the HaloTag protein

DOTA-tris(t-Bu)ester-PEG6-propargyl fam 4-(1-piperazinyl)-DOTA bifucational chelator containing an alkyne group, a PEG linker, and the macrocyclic chelator DOTA ( 1,4,7,10 tetraazacyclododecane 1,4,7,10 tetraacetic acid). It can be used in many different diagnostic and therapeutic applications, such as MRI contrast agents, PET and SPECT imaging agents, and radiotherapeutic agents. Product Name DOTA tris(t Bu)ester PEG6 propargyl Synonyms CAS Number n a Related CAS Molecular Formula C43H79N5O13 Molecular