DBCO-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-Exatecan Size:10mg 611 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCCCCCN=[N+]=[N-])CCN(CC(O)=O)CC1 Purity (HPLC)

611 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCCCCCN=[N+]=[N-])CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

15 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCCl)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

3-dione Synonyms 1-(²H3)methyl-2

298 SMILES OCC#CC1=CC=C2C(CN(C3CCC(=O)NC3=O)C2=O)=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Pettersson

DBCO-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-Exatecan Size:10mg 611 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCCCCCN=[N+]=[N-])CCN(CC(O)=O)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a DBCO Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further