Mal-Propionyl-PEG4-Val-Ala-PAB(m-PEG8)-Exatecan fluorescein The Mal-Propionyl group may also

The Mal-Propionyl group may also improve retro-Michael addition stability during antibody conjugation

Product Name Mal-Propionyl-PEG6-Gly-Gly-Phe-Gly-PAB(m-PEG4) Synonyms CAS Number Related CAS Molecular Formula C54H80N8O20 Molecular Weight 1161

519 Purity (HPLC) >= 95% Solubility DMSO

Product Name Azide-Lys(m-PEG4)-Val-Ala-PAB(m-PEG4) Synonyms CAS Number Related CAS Molecular Formula C41H70N8O14 Molecular Weight 899

4-diethylamine 4HCl CAS Number 852392-58-6 Related CAS 6531-38-0 Molecular Formula C8H24Cl4N4 Molecular Weight 318

Mal-Propionyl-PEG4-Val-Ala-PAB(m-PEG8)-Exatecan fluorescein The Mal-Propionyl group may alsoSOLU KNEX cleavable linker features a Val Ala dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG4 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I