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Indisulam promotes the recruitment of RBM39 (RNA binding motif protein 39) to the CUL4-DCAF15 E3 ubiquitin ligase
molecular biology
942 Purity (HPLC) >= 95% Solubility DMSO
4 Purity (HPLC) >= 95% Solubility DMSO
Product Name Mal-Propionyl-PEG8-Val-Cit-PAB(m-PEG4)-MMAE Synonyms CAS Number Related CAS Molecular Formula C93H155N13O31 Molecular Weight 1951
Mal-Propionyl-PEG6-Val-Ala-PAB(m-PEG4)-Exatecan Size:5mg Indisulam promotes the recruitment ofSOLU KNEX cleavable linker features a Val Ala dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG6 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I
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