Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG8)-Exatecan Size:1mg biotin-streptavidin binding or hydrophobic effects)

biotin-streptavidin binding or hydrophobic effects)

and exhibits excellent photostability

Product Name DOTA-tris(t-Bu)ester-C5-propanamido-maleimide Synonyms CAS Number n/a Related CAS Molecular Formula C40H69N7O10 Molecular Weight 808

NCCOCCOCC(=O)NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

455 SMILES OC(=O)CCCCCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG8)-Exatecan Size:1mg biotin-streptavidin binding or hydrophobic effects)SOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG4 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I