Azide-Propionyl-Val-Ala-PAB(m-PEG8)-PNP DBCO 821 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])CCN(CC(O)=O)CC1 Purity (HPLC)

821 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Mal-Propionyl-Beta-Ala-Val-Cit-PAB(m-PEG8) Synonyms CAS Number Related CAS Molecular Formula C46H74N8O17 Molecular Weight 1011

Product Name 5-(Methoxy-d3)-2-methylaniline Synonyms CAS Number n/a Related CAS Molecular Formula C8H11NO Molecular Weight 140

Product Name: Lissamine rhodamine B alkyne Synonyms: Sulforhodamine B alkyne CAS Number: N/A Molecular Formula: C60H66N6O12S4 Molecular Weight: 595

which leverages the high-affinity TMP-eDHFR interaction

Azide-Propionyl-Val-Ala-PAB(m-PEG8)-PNP DBCO 821 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])CCN(CC(O)=O)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Ala dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating leaving group, enabling efficient and selective conjugation of the payload to the linker. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine