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The covalent linkage between the HaloTag ligand and HaloTag protein enables rapid isolation and purification
E7820 induce targeted degradation of the splicing factor RBM39 through recruitment of the E3 ubiquitin ligase CRL4DCAF15
Product Name: 5(6)-FAM PEG3 azide Synonyms: 5-(and 6)-Carboxyfluorescein-PEG3-Azide CAS Number: N/A Molecular Formula: C29H28N4O9 Molecular Weight: 576
The methyl group is inert in this context and cannot undergo the nucleophilic substitution reaction that the chloroalkane relies on to bind the HaloTag protein
piperidinyl)
Azide-Propionyl-Val-Cit-PAB(m-PEG8)-Exatecan Size:5mg The covalent linkage between theSOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC
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