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which recruit the VHL or CRBN-ubiquitin E3 ligases to induce the degradation of CLIP-fusion proteins
The payload is monomethyl auristatin E (MMAE)
933 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCOCCN=[N+]=[N-])CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
Product Name Azide-Lys(m-PEG4)-Val-Ala-PAB(m-PEG4) Synonyms CAS Number Related CAS Molecular Formula C41H70N8O14 Molecular Weight 899
Product Name Lenalidomide-C2-acid Synonyms Lenalidomide-4'-C2-acid CAS Number 2338824-28-3 Related CAS Molecular Formula C16H17N3O5 Molecular Weight 331
Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4)-Exatecan Size:10mg which recruit the VHL orSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG6 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I
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