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Mal-Propionyl-PEG4-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan Size:5mg NCC(=O)NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95%

SKU: 23583043376

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Description

NCC(=O)NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name: Thalidomide-O-C5-amine Synonyms: 1H-

Product Name Mal-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG4)-Exatecan Synonyms CAS Number Related CAS Molecular Formula C77H96FN11O23 Molecular Weight 1562

Product Name: 5(6)-ROX alkyne Synonyms: 5-(and 6)-Carboxy-X-rhodamine alkyne CAS Number: N/A Molecular Formula: C36H33N3O4 Molecular Weight: 571

4-diethylamine 4HCl CAS Number 852392-58-6 Related CAS 6531-38-0 Molecular Formula C8H24Cl4N4 Molecular Weight 318

Mal-Propionyl-PEG4-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan Size:5mg NCC(=O)NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95%SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG4 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent

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