Mal-Propionyl-PEG8-Val-Cit-PAB(m-PEG4)-PNP Size:100mg Product Name Thalidomide-O-PEG1-C2-acid Synonyms Thalidomide-4'-O-PEG1-C2-acid

Product Name Thalidomide-O-PEG1-C2-acid Synonyms Thalidomide-4'-O-PEG1-C2-acid CAS Number n/a Related CAS Molecular Formula C18H18N2O8 Molecular Weight 390

Product Name tert-butyl 2-{4-[(piperidin-4-yl)methyl]piperazin-1-yl}acetate Synonyms CAS Number n/a Related CAS Molecular Formula C16H31N3O2 Molecular Weight 297

338 SMILES OC(=O)CCC(=O)NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

492 SMILES O=C(COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1)NCCOCCOCCOCC#C Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

341 SMILES O=C1N(CC2=C(NCCC#C)C=CC=C12)C1CCC(=O)NC1=O Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Mal-Propionyl-PEG8-Val-Cit-PAB(m-PEG4)-PNP Size:100mg Product Name Thalidomide-O-PEG1-C2-acid Synonyms Thalidomide-4'-O-PEG1-C2-acidSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG8 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating