Thalidomide-5'-O-propargyl pab Iberdomide promotes degradation of Aiolos

Iberdomide promotes degradation of Aiolos and Ikaros proteins

653 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCCNC(=O)CCN2C(=O)C=CC2=O)CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

RSC Medicinal Chemistry

953 Purity (HPLC) >= 95% Solubility DMSO

88 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCN=[N+]=[N-])CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Thalidomide-5'-O-propargyl pab Iberdomide promotes degradation of AiolosDegrader building block for targeted protein degradation. Contains an E3 ligase ligand with a linker and a function group, which can be conjugated to target protein ligands through straightforward chemical reactions. Product Name Thalidomide 5' O propargyl Synonyms CAS Number 2226303 74 6 Related CAS Molecular Formula C16H12N2O5 Molecular Weight 312. 281 SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)C2=CC(OCC#C)=CC=C12 Purity (HPLC) >= 95% Shipping Conditions Room