Its a nifty little spell that is incredibly good because it doesnt just target creatures, which makes it incredibly versatile as you can use it to protect a land from a timely Wasteland if needed, especially if you can keep returning the Safekeeping from your graveyard by using cards like Eternal Witness
These treatments can be found exclusively in Collector Boosters, the best place to get all of the amazing treatments in this release
Many decks interested in wraths want to play blue anyway, and being uncounterable is way more relevant than preventing regeneration, since its mostly been phased out, and common protection spells use phasing or indestructible

Aeve, Progenitor Ooze Arboreal Alliance Biowaste Blob Bramble Sovereign Bushy Bodyguard Caller of the Pack Caller of the Untamed Chatterstorm City of Death Domesticated Mammoth (playtest) Druid's Deliverance Dual Nature Elvish Hydromancer Endless Swarm Esika's Chariot Fanatic of Rhonas Fin-Clade Fugitives Full Flowering Giant Adephage Hatchery Sliver Honored Hydra Horncaller's Chant Hunting Pack Jubilation Life Finds a Way Ochre Jelly Parallel Evolution Pawpatch Recruit Penumbra Umbra (playtest) Polygoyf Polyraptor Pool of Vigorous Growth Resilient Khenra Rootcast Apprenticeship Rust-Shield Rampager Scion of Calamity Scurry of Squirrels Scute Swarm Second Harvest Selesnya Eulogist Spawnwrithe Splitting Slime Springheart Nantuko Sprouting Phytohydra Tender Wildguide Timeless Witness Vaultborn Tyrant Watchful Radstag
But thats the kind of paperwork Im always happy to do